As a preparation for an exam on the pathophysiology of the kidney, I created an overview scheme of most of the channels that are responsible for the kidneys fluid, electrolyte, and therefore pressure regulating actions. This overview turned out to be rather technical, but it contains a lot of information. I just tried to put it on one page. This of course does not imply that it is helpful for every individual studying the kidney. All the abbreviations can conveniently be found on trustworthy sites such as Wikipedia. If you have questions/comments, just tell me!

Kidney Physiology Overview

An overview of kidney physiology related channels.

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Shortly I will start with an internship at the Department of Molecular Microbiology at Rijksuniversiteit Groningen (Prof. Driessen). There I will deal with the mechanisms of protein secretion in bacteria. I will in more detail concentrate on the Sec-pathway. The dominant part of this process is achieved by a multi-subunit translocase. This protein consists out of a channel (trimeric SecYEG) which penetrates the lipid membrane. In addition SecA protein belongs to the complex which is some sort of molecular motor that mediates the stepwise protein translocation through the channel at the cost of ATP. Other important proteins during translocation are SecD, SecF and YajC which associate to SecYEG). Chaperones such as SecB guide secretory proteins through the channel, while co-translational targeting via the signal recognition particle (SRP) and its receptor SRPR is also possible. The latter case also occurs for membrane proteins.

The reasearch of the department, generally spoken, is to identify structure-function relations of the above named translocase. In order to achieve this it is important to concentrate on the chain of events during the process and the conformational changes of the participating molecules.

Shortly there will be more information on the topic. On the following website more information can be found: http://www.rug.nl/fmns-research/molecular-microbiology/research/proteintranslocation